Thursday, March 14, 2013

Martian rock points to life-friendly conditions

Trace the Curiosity rover's journey to Mars and see the pictures that the six-wheeled robot has sent back from the Red Planet.

By Alan Boyle, Science Editor, NBC News

Powder drilled out of a rock on Mars contains the best evidence yet that the Red Planet could have supported living microbes billions of years ago, the team behind NASA's Curiosity rover said Tuesday.

"I think this is probably the only definitively habitable environment that we have described and recorded," said David Blake, a scientist at NASA's Ames Research Center who is the principal investigator for Curiosity's CheMin lab.

The findings are in line with what the scientists hoped to find when they sent the 1-ton, six-wheeled laboratory to Mars' Gale Crater. "It wasn't serendipity that got us here. It was the result of planning," Caltech's John Grotzinger, the $2.5 billion mission's project scientist, told reporters at NASA Headquarters in Washington on Tuesday.


Serendipity did, however, play a part in being able to find the evidence so soon, he said. Curiosity's handlers had planned to have the rover head for a 3-mile-high (5-kilometer-high) mountain in the middle of the crater. But when the rover landed, the science team decided to send Curiosity on a detour to a geologically interesting area in the opposite direction, nicknamed Yellowknife Bay. Preliminary readings showed that the area had been a riverbed or lake bed in ancient times.

Last month, the rover finally got a chance to drill into a Martian rock that was named John Klein, after a member of the mission team who died in 2011. Curiosity fed tablespoons of the ground-up gray powder into its two onboard chemical labs: CheMin (Chemistry and Mineralogy) and SAM (Sample Analysis at Mars). The results were announced at Tuesday's news briefing.

Scientists said the powder contained the elemental ingredients of life ? including sulfur, nitrogen, hydrogen,?oxygen, phosphorus and carbon. More significantly, they found that clay minerals made up at least 20 percent of the sample. On Earth, these clays are produced when relatively fresh water reacts with igneous minerals such as olivine. The scientists also found calcium sulfate, which suggested that the water had a neutral or mildly alkaline balance.

NASA / JPL-Caltech / Ames

A side-by-side comparison shows the X-ray diffraction patterns of two samples collected by Curiosity. The left side shows data from a sample collected from a drift of windblown dust, and the right side shows data from the powder drilled out of the John Klein rock. The John Klein readings show an abundance of phyllosilicate, a class of clay minerals called smectites that form by the action of relatively pure and neutral pH water on minerals.

NASA / JPL-Caltech / Cornell / MSSS

The left image shows Wopmay rock in Endurance Crater, as studied by NASA's Opportunity rover. The right image shows Sheepbed in Yellowknife Bay, as studied by Curiosity. Scientists say both rocks were formed in the presence of water, but the water at Wopnay was highly acidic and salty, while the water at Sheepbed had a more neutral pH and lower salinity.

Earlier NASA missions had found evidence that?salty, acidic water was once present on Mars, but that extreme environment would have been challenging for today's Earth-type organisms. Curiosity's chemical analysis produced a different result: The water that was available during the formation of the rock at Yellowknife Bay, billions of years ago, could have supported the kind of life commonly found on Earth.

"We have found a habitable environment which is so benign and supportive of life that probably if this water was around, and you had been on the planet, you would have been able to drink it," Grotzinger said.

The scientists said they were surprised to find a mixture of oxidized and non-oxidized chemicals, allowing for the type of chemistry that earthly microbes use to generate the energy they need for survival. This partial oxidation was first hinted at when the drill cuttings were revealed to be gray rather than red.

"The range of chemical ingredients we have identified in the sample is impressive, and it suggests pairings such as sulfates and sulfides that indicate a possible chemical energy source for microorganisms," SAM principal investigator Paul Mahaffy said in a NASA news release.

NASA said another drilled sample would be used to help confirm the chemical findings for several of the trace gases that were analyzed by the SAM instrument.

The current plan calls for Curiosity to conduct experiments in the Yellowknife Bay for weeks or months longer, and then begin a roughly 6-mile (10-kilometer) drive to the big mountain, known as Mount Sharp or Aeolis Mons. Scientists will look for further evidence of ancient organic chemistry hidden in the mountain's many layers of rock.

The primary aim of Curiosity's two-year primary mission is to find evidence of past habitability ? in particular,?organic carbon compounds that could have played a role in the chemistry of life billions of years ago. Grotzinger said Curiosity's scientists will focus on the systematic search for organic carbon now that they had "the issue of habitability in the bag."

NASA intends to follow up on Curiosity's findings with future Mars missions, including the $500 million MAVEN orbiter (due for launch this year), the $425 million InSight drill-equipped lander (set for 2016 launch) and another Curiosity-like rover that's scheduled to be sent out in 2020.?

More about Mars:


Alan Boyle is NBCNews.com's science editor. Connect with the Cosmic Log community by "liking" the log's?Facebook page, following?@b0yle on Twitter?and adding the?Cosmic Log page?to your Google+ presence. To keep up with Cosmic Log as well as NBCNews.com's other stories about science and space, sign up for the Tech & Science newsletter, delivered to your email in-box every weekday. You can also check out?"The Case for Pluto,"?my book about the controversial dwarf planet and the search for new worlds.

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Source: http://cosmiclog.nbcnews.com/_news/2013/03/12/17285137-nasa-says-mars-curiosity-rover-sees-traces-of-life-friendly-conditions-in-rock?lite

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New type of bacteria discovered in lake beneath Antarctic ice

Scientists say that the type of microbe, which has been locked in the lake under the ice for millions of years, is only 86 percent similar to other known types.?

By Elizabeth Howell,?OurAmazingPlanet Contributor / March 8, 2013

Russia's Vostok Station, in a photograph taken during the 2000 to 2001 field season.

Josh Landis, National Science Foundation

Enlarge

A new type of microbe has been found at a lake buried under Antarctica's thick ice, according to news reports. The find may unveil clues of the surrounding environment in the lake, according to scientists.

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The bacteria, said to be only 86 percent similar to other types known to exist on Earth, was discovered in a water sample taken from?Lake Vostok, which sits under more than 2 miles (3 kilometers) of Antarctic ice. The freshwater lake has likely been buried, unaltered, under the ice for the past million years.

Russian scientists reportedly obtained the water samples in 2012 when they drilled?all the way down to the lake's surface. They ran the bacteria's composition through a global database and were not able to find anything similar to its type. Scientists couldn't even figure out the bacteria's descendents.

"After putting aside all possible elements of contamination, DNA was found that did not coincide with any of the well-known types in the global database," said Sergey Bulat, a geneticist at the Saint Petersburg Institute of Nuclear Physics, in a quote attributed in media reports to RIA Novosti news service.

"We are calling this life form unclassified and unidentified," he added.

Understanding the environment

While the bacteria still needs to be confirmed, its potential is already drawing attention from other Antarctic scientists.

Life forms are shaped by the environment they live in, and often shape that environment in return. Finding out more about bacteria in Lake Vostok, therefore, will help researchers picture what living in the lake is like for these tiny microorganisms.

"The study of looking at the organisms and their environment is really the study of ecology," said Alison Murray, an associate research professor at the Desert Research Institute (an environmental research group based in Nevada) who also?does Antarctic research?herself.

"By learning more about the life forms that live in Vostok, that will probably teach us a bit about the lake itself," Murray told OurAmazingPlanet.

Murray, who is familiar with the Russian researchers' work, said the group is a "very careful team of scientists" who would have put the bacteria through several validity tests before releasing the news.

Understanding bacterial life on Earth is also considered a possible research direction for finding life on other planets,?including Mars.

'If this is real, it is very exciting'

The 86 percent similarity figure, to Murray, is a plausible indicator that this could be a new type of bacteria. Since all Earthly life is related to each other in some way, anything below about 80 percent would draw concern, Murray added.

At least one other scientist, however, expressed caution about the finding, saying that more information is needed before drawing conclusions.

"If this is real, it is very exciting," Peter Doran, a microbiologist at the University of Illinois at Chicago, wrote in an e-mail to OurAmazingPlanet. He is a frequent visitor to the Arctic and Antarctica for his research.

"I would caution, though, that this type of 'press release' science is a little dangerous. It really needs to go through the rigor of peer review by other experts in the field before I'll jump on board," he said. "Having others looking at their methods and data will provide support for their conclusions."

Russian scientists successfully?dug through to the buried lake?again in January this year, retrieving more samples for later analysis.

Meanwhile, a British team had to?call off their quest in December?to dig to Lake Ellsworth, another Antarctic subglacial lake, after they encountered technical difficulties.

Follow Elizabeth Howell?@howellspace. Follow?OurAmazingPlanet?@OAPlanet,Facebookand?Google+.

Copyright 2013?LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://rss.csmonitor.com/~r/feeds/science/~3/4YKU_6V40lo/New-type-of-bacteria-discovered-in-lake-beneath-Antarctic-ice

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Furyk opts for the straight and narrow

Jim Furyk hits his tee shot on the 17th hole during a practice round for the Tampa Bay Championship golf tournament Wednesday, March 13, 2013, in Palm Harbor, Fla. (AP Photo/Chris O'Meara)

Jim Furyk hits his tee shot on the 17th hole during a practice round for the Tampa Bay Championship golf tournament Wednesday, March 13, 2013, in Palm Harbor, Fla. (AP Photo/Chris O'Meara)

Jim Furyk reacts as he misses a putt on the 17th green during a practice round for the Tampa Bay Championship golf tournament Wednesday, March 13, 2013, in Palm Harbor, Fla. (AP Photo/Chris O'Meara)

PALM HARBOR, Fla. (AP) ? Jim Furyk goes into the Tampa Bay Championship at No. 5 in driving accuracy on the PGA Tour and No. 146 in distance off the tee.

That's not unusual. He has taken the short and narrow to great lengths on tour. Only five active players ? Tiger Woods, Phil Mickelson, Vijay Singh, Davis Love III and Ernie Els ? have more than his 16 career titles. Furyk also has a U.S. Open, a FedEx Cup title and appearance on 15 consecutive U.S. teams for the Ryder Cup or Presidents Cup.

So it was surprising to hear Furyk talk about the first time he played Innisbrook as a teenager, he was one of the big hitters.

"Most people laugh when they hear that," Furyk said Wednesday.

He said he was among the longest hitters on his team when he first arrived at Arizona, and his tee shots were "average length at best" when he left. Some of that had to do with changes in equipment. And some of that had to do with his decision to keep the ball in play.

"I went through a learning curve in golf and life, as I think every college kid does at one time or another," Furyk said. "I think going into my senior year, the light probably went off and I said, 'Oh, shoot, next year I'm supposed to get a job.' I realized I had to start playing a little better, and I started working on things I needed to improve on, and I thought driving the ball straighter was going to be one of those."

That's why he loves returning to the Copperhead course.

Furyk won the Tampa Bay Championship in 2010, ending a 32-month drought. A year ago, he made a late birdie to get into a four-way playoff that lasted only one hole when Luke Donald hit a 7-iron out of the rough to 6 feet for birdie.

Power never hurts at Innisbrook. Past champions include Gary Woodland and Vijay Singh. Position off the tee counts just as much, if not more.

"This doesn't really look like your stereotypical Florida golf course," Furyk said. "It's not that flat. There are not houses on both sides of the fairways. ... You have to hit some shots to put the ball in the fairway. You're just not going to tee it up and bomb it here. You have to think your way around and play to certain sports of the fairway and hit some crisp iron shots.

"If it's a place where you can tee it up 4 inches and rear back and let it fly and go find it, hit it again, it's probably a place where I'm going to take the week off."

The Tampa Bay Championship gets overlooked as the third leg of the Florida Swing. So much attention is on the Honda Classic, which was boosted by its spot on the schedule between two World Golf Championships, and is helped by Woods and Rory McIlroy playing because they live in south Florida. The WGC event was last week at Doral. The Arnold Palmer Invitational is next week at Bay Hill.

Innisbrook is a gem, however, considered by many players to be the best tournament course in Florida. It features surprising changes in elevation, especially for Florida. Water only comes into play on seven holes. The fairways have subtle movement and are lined by trees, and the course typically is firm and fast.

"It's a golf course you have to really think your way around, shape some shots off the tee," Donald said. "It really does test all parts of your game from tee shots to really getting the iron shots in the right positions on the greens, which are some of the most sloped and fast greens we play all year. And they are very quick right now. It's a thinking man's course."

Four of the top 10 players in the world ? Donald, Louis Oosthuizen, Adam Scott and Matt Kuchar ? are at the Tampa Bay Championship, with 21 of the top 50. The list includes Geoff Ogilvy, who at No. 49 is still searching for that one good week that will lock up a spot in the Masters.

And there are plenty of newcomers this week, with four players getting into the tournament because of finishing in the top 10 at the Puerto Rico Open last week. That includes 19-year-old Jordan Spieth and Peter Uihlein, who last played here in 2011 as the U.S. Amateur champion.

Furyk is not interested in redemption ? for last year at Innisbrook, for any of the four tournaments he had a chance to win during a most frustrating season.

It was a different kind of season than in 2011, when he had only three top 10s against full fields and finished 53rd on the PGA Tour money list, his lowest position since his rookie season in 1994. He felt he played just as well as he did in 2010, when he won three times, except that he didn't win at all.

"I was really happy with a lot of things I did well in 2012, but it was going to be a frustrating, disappointing year to look back on with the finishes, and not being able to finish things off," he said. "In a lot of ways, it was better than 2010 in all the unimportant ways ? the statistics. But all the important ways ? finishing off tournaments and winning ? it was a frustrating year."

There was that snap hook with a fairway metal off the 16th tee that dropped him out of a tie for the lead at the U.S. Open, and he never caught up. He had a one-shot lead and was in the middle of the 18th fairway at Firestone when he chopped his way to a double bogey and lost by one. He had a share of the 54-hole lead at Sea Island and finished two shots behind.

And that doesn't include the Ryder Cup, where he had a 1-up lead with two holes to play and lost to Sergio Garcia.

Furyk figured the best way to get over it was to forget about it.

"I tried to figure out where I went wrong and what I could have done better and how I could have fixed it, and then you really can't dwell on it," Furyk said. "At that point, you beat yourself up over and over again. I tried to blow off steam, but I really tried to get away and really get my mind fresh."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-03-14-GLF-Tampa-Bay/id-e523f073579f4dcfa9c1e4b73810679c

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Students bring home big prizes for science projects

Intel Science Talent Search awards teens for research

By Meghan Rosen

Web edition: March 12, 2013

WASHINGTON ? Sara Volz gasped in amazement when she heard her name called. The 17-year-old finalist had just been named the grand-prize winner at the March 12 awards gala of the 2013 Intel Science Talent Search awards. She was going home with $100,000.

Volz, a bubbly high school student from Colorado Springs, Colo., rushed across the stage of the National Building Museum?s Great Hall, a cavernous room gussied up for the black-tie event with spotlights, golden tablecloths and red roses. Decked out in a lavender satin dress, the teenager laughed and smiled as blue and white balloons rained down on the winners.

Volz?s project, an experiment to pump up algal oil levels for use in biofuel, began in her bedroom. The teenager grew algae in 40 glass flasks underneath her loft bed, and used an herbicide to kill cells that dribbled out only tiny amounts of oil. Over multiple generations of algal growth, the protocol resulted in cells with naturally elevated levels of oil production.

Volz tended her algae garden almost every day, checking it regularly for evaporation and keeping it on strict light-dark cycles. ?It?s basically like having a pet,? she joked. This fall, Volz plans to head to college at MIT.

Her winning research topped the projects of 39 other STS finalists. In total, the competition received 1,712 entries from 42 states, the District of Columbia, Guam and two U.S. overseas schools.

?SSP and Intel could not be prouder of the Intel Science Talent Search finalists of 2013,? said Elizabeth Marincola, president of SSP and publisher of Science News. "We eagerly look forward to following their contributions in the coming years in every field of human endeavor."

At the ceremony, the Intel Foundation handed out $630,000 to the 40 finalists of the Intel STS, a competition run by the Society for Science & the Public, publisher of Science News, and first established in 1942. Intel began sponsoring the competition in 2008.

The Intel Foundation awarded second place and $75,000 to Jonah Kallenbach from Ambler, Penn. The 17-year-old figured out how to better predict how different drugs latch onto proteins. His work could give researchers a new method for designing drugs that target specific molecules.

Third place and $50,000 went to Adam Joseph Bowman, 17, of Brentwood, Tenn., who constructed a plasma gun in his garage from parts he bought on eBay. He also designed an inexpensive fiber optics system to follow the plasma?s movement. ?I?ve always enjoyed building things,? he said. Bowman has been refining his plasma gun since he was 14.

Hannah Kerner Larson, 18, of Eugene, Ore., won fourth place and $40,000 for her project on a type of abstract mathematical structure called fusion categories. Fifth place and $30,000 went to Peter Kraft, 17, of Munster, Ind., who created 10 new molecules that could help improve hydrogen storage in fuel cells.

Sixth and seventh place winners Kensen Shi and Samuel Zbarsky each took home $25,000. Shi, 17, of College Station, Texas, designed an algorithm that helps robots navigate around obstacles. In his free time, he said, he likes to solve Rubik?s Cubes. Zbarsky, 17, of Rockville, Md., worked on a mathematics project that could help make computer networks more efficient.

Eighth, ninth and 10th places each came with $20,000 and went to Brittany Wenger, Akshay Padmanabha and Sahana Vasudevan. Wenger, 18, of Sarasota, Fla., created a computer software program to analyze breast cancer biopsy samples; Padmanabha, 16, of Collierville, Tenn., devised a method for detecting seizures; Vasudevan, 16, of Palo Alto, Calif., worked on a math project to speed up computer algorithms.

The other 30 finalists each received $7,500, and along with the top 10 spent a week on an all-expenses paid trip to Washington. On March 10 the finalists presented their research to the public at the National Geographic Society.

The finalists elected Alexa Danzler to receive the Glenn T. Seaborg award, a distinction honoring the late Nobel Prize?winning chemist and longtime Science Talent Search judge.

These 40 young finalists will change the world, said Jane Shaw, former Intel Corp. board chairman. "It's such an honor to help them launch their careers, right here this evening."

Source: http://www.sciencenews.org/view/generic/id/348935/title/Students_bring_home_big_prizes_for_science_projects

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Monday, March 11, 2013

Kim Jong-Un, Dennis Rodman DOMINATE Pathetic Americans in NBA Jam!

Source: http://www.thehollywoodgossip.com/2013/03/kim-jong-un-dennis-rodman-dominate-pathetic-americans-in-nba-jam/

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Obama jokes of recent controversies at Gridiron dinner

WASHINGTON - President Obama made light of the recent spat between White House economic adviser Gene Sperling and journalist Bob Woodward Saturday night when he turned on his comedic charm before an elite group at the annual Gridiron Club Dinner.

"This whole brouhaha has had me a little surprised," President Obama said. "Who knew Gene [Sperling] could be so intimidating? Or let me phrase it differently: Who knew anybody named Gene could be this intimidating?

"You notice that some folks couldn't make it this evening. It's been noted that Bob Woodward sends his regrets, which Gene Sperling predicted. ? I know that some folks think we responded to Woodward too aggressively, but hey, can anybody tell me when an administration has ever regretted picking a fight with Bob Woodward? What's the worse that could happen?" Obama said.

The argument between Sperling and Woodward came to the spotlight after Woodward revealed the White House economic adviser told him he would "regret staking out that claim" that President Obama was "moving the goal posts" on additional revenue.

PHOTOS: President Obama's First Term Captured In Photos

In his speech before the exclusive Gridiron Club Dinner, the president addressed the grievances raised by the press corps about the administration's lack of access and transparency.

"Some of you have said that I'm ignoring the Washington press corps, that we're too controlling. You know what, you're right. I was wrong. I want to apologize - in a video you can watch exclusively at Whitehouse.gov," Obama said.

The Gridiron Club is one of Washington, D.C.'s most exclusive organizations for journalists. The annual event, which held its 128th dinner Saturday, features musical skits poking fun at Republican and Democratic lawmakers.

As the president reaches out to Congress this week to reach an agreement on replacing the sequester cuts, he incorporated the current fiscal fight into his comedy routine.

"Because of sequester, they cut my tails. My joke writers have been placed on furlough," he said. "There is one thing in Washington that didn't get cut: The length of this dinner. Yet more proof that the sequester makes no sense."

The president highlighted a recent thirsty mishap by a popular politician on the Republican side - Florida Sen. Marco Rubio.

"Of course, as I begin my second term, our country is still facing enormous challenges," the president said, as he took a long sip of water. "That, Marco Rubio, is how you take a sip of water."

Despite roasting Republicans, the president didn't spare those on the Democratic side, poking fun at Secretary of State John Kerry and Vice President Joe Biden, who may decide to launch a 2016 presidential bid.

"Let's face it Hillary [Clinton] is a tough act to follow. ? Frankly, though, I think it's time for him to stop showing up at work in pant suits. It's a disturbing image. I don't know where he buys them. He's a tall guy," Obama said of Kerry.

"It's no secret that my vice president is still ambitious. But let's face it, his age is an issue. Just the other day I had to take Joe aside and say, 'Joe you are way too young to be the pope,'" he said.

The president's appearance at the Gridiron Dinner marked his second time addressing the elite club. He attended the dinner one other time, in 2011. In addition to the president, Sen. Amy Klobuchar, D-Minn., and Louisiana Gov. Bobby Jindal headlined the dinner for each of their respective parties.

While numerous journalists attended the festivities, TV cameras were prohibited form covering the evening's event.

But amid all the laughs of the evening, the president extended an appreciation for the journalists that cover him each day.

"In an age when all it takes to attract attention is a Twitter handle and some followers, it's easier than ever to get it wrong. But it's more important than ever to get it right. And I'm grateful for all the journalists who do one of the toughest jobs there is with integrity and insight and dedication and a sense of purpose that goes beyond a business model or a news cycle," he said.

Also Read

Source: http://news.yahoo.com/obama-makes-light-recent-controversies-054406197.html

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Venezuela candidate: Govt exploits Chavez death

Opposition leader Henrique Capriles gestures during a press conference in Caracas, Venezuela, Sunday, March 10, 2013. Capriles announced he will run in elections, scheduled for April 14, to replace late President Hugo Chavez, who died of cancer on March 5. (AP Photo/Rodrigo Abd)

Opposition leader Henrique Capriles gestures during a press conference in Caracas, Venezuela, Sunday, March 10, 2013. Capriles announced he will run in elections, scheduled for April 14, to replace late President Hugo Chavez, who died of cancer on March 5. (AP Photo/Rodrigo Abd)

People queue outside the military academy where Venezuela's late President Hugo Chavez is lying in state in Caracas, Venezuela, Sunday, March 10, 2013. Chavez died on March 5 after a nearly two-year bout with cancer. He was 58. (AP Photo/Ariana Cubillos)

People rest outside the military academy where Venezuela's late President Hugo Chavez is lying in state in Caracas, Venezuela, early Sunday, March 10, 2013. People continue to parade to see the body of Chavez, who died of cancer on March 5. (AP Photo/Ariana Cubillos)

People enter the military academy to see the body of Venezuela's late President Hugo Chavez lying in state in Caracas, Venezuela, Sunday, March 10, 2013. Chavez died on March 5 after a nearly two-year bout with cancer. He was 58. (AP Photo/Ariana Cubillos)

People queue outside the military academy to see the body of Venezuela's late President Hugo Chavez lying in state in Caracas, Venezuela, Sunday, March 10, 2013. Chavez died of cancer on March 5. He was 58. (AP Photo/Ariana Cubillos)

(AP) ? Venezuelan opposition leader Henrique Capriles on Sunday launched what many consider a doomed candidacy to replace Hugo Chavez with a no-holds-barred attack against a government he accused of coldly betraying Venezuelans' trust.

Chavez's political heirs have toyed with Venezuelans' hopes, lying to them about his deteriorating health by suggesting he could recover and even producing decrees he supposedly signed, said Capriles, whom Chavez defeated by a 12-point margin in October.

He did not make direct reference to the decision to embalm Chavez and put him on permanent display, but he said: "You are playing politics with the president's body."

Capriles accused the socialist government that Chavez left behind after 14 years in power of meticulously planning a campaign to assure the election of Nicolas Maduro, Chavez's desired successor.

"Who knows when President Chavez (really) died," he asked. The government says Chavez succumbed to cancer on Tuesday after a nearly two-year battle. It has offered almost no clinical information.

Capriles also called Defense Minister Diego Molero a "disgrace" for publicly backing Maduro. The constitution forbids the military from taking political sides.

"Don't fool yourselves that you're the good and we're the bad," Capriles said in a 45-minute speech at his eastern Caracas campaign headquarters. "No, you're no better than us. I don't play with death. I don't play with pain."

A picture of Chavez behind him, Maduro appeared almost immediately afterward on state TV, accusing "the losing, miserable candidate" of defaming Chavez and his family.

He called Capriles a "fascist" trying to provoke violence by insulting the "crystalline, pure image of Commander Chavez."

"You have made the biggest mistake of your life," Maduro said. He said that if Chavez's family seeks legal action "don't say afterward that you are being politically persecuted."

Capriles, a state governor, acknowledged facing long odds against a candidate who wields vast public resources and a state media machine ? and has the backing of the country's electoral council.

"As one person said today, 'Capriles, they are taking you to a slaughterhouse. Are you going to be lowered into its meat grinder?'" he said.

Capriles said, however, that he felt he had no other choice.

"How am I not going to fight?" he said. "How are we not going to fight? This is not Capriles' fight. This is everybody's fight."

In some upper-class districts of the capital, people launched fireworks, shouted and honked horns as Capriles announced he would run. Political analysts wondered where the Capriles they witnessed on Sunday had been during last year's campaign.

Capriles laid out potential major themes for his campaign, bemoaning violent crime, persistent poverty and a troubled economy that led the government to devalue the currency last month by more than 30 percent.

The electoral council has set the vote for April 14. Formal campaigning begins just 12 days earlier.

Unlike Capriles, Maduro made repeated references to the possibility of violence in the superheated, abbreviated campaign ahead.

Yet he also called for calm.

"We have to continue to rise above every provocation with peace, peace, peace and peace," Maduro said. "Respect, respect, respect."

Opposition critics say Maduro's swearing-in Friday as acting president was unconstitutional. The charter designates the National Assembly interim head of state if a president-elect cannot be sworn in.

Capriles decided to run fully aware that a second presidential defeat could end his political career.

Political consultant Oswaldo Ramirez, who is advising the Capriles campaign, said the candidate must strike a balance between criticizing the failures of Chavez's government and Maduro's role in it, without being seen as attacking the late president.

"He can't speak badly of Chavez, because this feeling on the street is still in full bloom," Ramirez said.

Public opinion was as divided as always Sunday in a country that became dramatically more polarized during Chavez's 14-year rule.

"It's not fair," said Jose Mendez, a 54-year-old businessman of the choice the opposition leader faces. "(Maduro) has an advantage, because of everything they have done since Chavez's death, all the sentiment they've created ... But the guy has nothing. He can't hold a candle to Chavez."

But Ramon Romero said the opposition was just making excuses, and had no chance of victory in any case.

"Now their odds are even worse," said the 64-year-old waiter and staunch Chavez supporter. "They don't care about anyone, and we (the voters) have been lifted out of darkness."

___

Associated Press writers Jack Chang, Frank Bajak, Paul Haven and E. Eduardo Castillo contributed to this report.

Associated Press

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COMET? METEOR? ASTEROID? HERE'S HOW TO TELL THE DIFFERENCE (San Jose Mercury News)

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Friday, March 8, 2013

Salt Linked to Autoimmune Diseases

Nanowires used to disarm single genes in cells without harming or altering them were used to reveal that sodium chloride might cause harmful T-cell growth


table salt Salt may play a role in the overproduction of immune-system cells that attack an organism's own tissues. Image: MARIO TAMA/GETTY IMAGES

The incidence of autoimmune diseases, such as multiple sclerosis and type 1 diabetes, has spiked in developed countries in recent decades. In three studies published today in?Nature, researchers describe the molecular pathways that can lead to autoimmune disease?and identify one possible culprit that has been right under our noses ? and on our tables ? the entire time: salt.

To stay healthy, the human body relies on a careful balance: too little immune function and we succumb to infection, too much activity and the immune system begins to attack healthy tissue, a condition known as autoimmunity. Some forms of autoimmunity have been linked to overproduction of TH17 cells, a type of helper T cell that produces an inflammatory protein called interleukin-17.

But finding the molecular switches that cause the body to overproduce TH17 cells has been difficult, in part because conventional methods of activating native immune cells in the laboratory often harm the cells or alters the course of their development.

So when researchers heard a talk by Hongkun Park, a physicist at Harvard University in Cambridge, Massachusetts, about the use of silicone nanowires to disarm single genes in cells, they approached him immediately, recalls Aviv Regev, a biologist at the Massachusetts Institute of Technology (also in Cambridge) and a co-author on two of the studies.

Park showed last year that these nanowires can be used to manipulate genes in immune cells without affecting the cells? functions. For the first of the?Nature?studies, Regev and her colleagues used Park's technology to piece together a functional model of how TH17 cells are controlled, she says. ?Otherwise,? she says, they would have been only ?guessing in the dark.?

In the second study, an affiliated team of researchers observed immune cell production over 72 hours. One protein kept cropping up as a TH17-signal: serum glucocorticoid kinase 1 (SGK1), which is known to regulate salt levels in other types of cells.?The researchers found that mouse cells cultured in high-salt conditions had higher SGK1 expression and produced more TH17 cells than those grown in normal conditions.

?If you incrementally increase salt, you get generation after generation of these TH17 cells,? says study co-author Vijay Kuchroo, an immunologist at Brigham and Women?s Hospital in Boston, Massachusetts.

In the third study, researchers confirmed Kuchroo?s findings, in mouse and human cells. It was ?an easy experiment ? you just add salt?, says David Hafler, a neurologist at Yale University in New Haven, Connecticut, who led the research.

But could salt change the course of autoimmune disease? Both Kuchroo and Hafler found that in a mouse model of multiple sclerosis, a high-salt diet accelerated the disease?s progression.?

All this evidence, Kuchroo says, ?is building a very interesting hypothesis [that] salt may be one of the environmental triggers of autoimmunity?.

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